Radiation ― A Double-Edged Sword

Radiation is a well-known carcinogen to humans, yet it remains valuable for diagnosis and treatment. To uncover the molecular mechanisms behind this double-edged effect on human health, we are conducting cutting-edge research using a variety of approaches, including microbeams, animal models, and large-scale cohorts. Our overarching aim is to both develop next-generation radiotherapeutic technologies and establish personalized systems for assessing radiation risk.

Hisanori Fukunaga, MD, PhD

Principal Investigator

News

April 1, 2026

Welcome to newcomers (2 undergraduate students and 1 graduate student), who have joined the Fukunaga lab.

March 28, 2026

Our research paper has been published online in Free Radical Biology and Medicine.

Seino R, Kubo H, Ikeda A, Fukunaga H. Mitochondrial DNA alterations in mothers and offspring following in utero exposure to ionizing radiation.

Click here for the journal website of our article.

Click here for the press release (Japanese).

March 23, 2026

The Japanese translation of ICRU Report 95 has been published online by the Nuclear Regulation Authority, Japan.

Dr. Fukunaga served as a member of the Japanese Translation Committee of ICRP Publications. On this occasion, the committee also undertook the translation of an ICRU report.

Click here for the Japanese translation of ICRU Report 95 (Japanese).

March 11, 2026

Fifteen years have passed since the 2011 Great East Japan Earthquake. We remember the lives lost and express our deepest condolences to all those affected. We remain committed to advancing research that contributes to the protection of human health and future generations.

February 12, 2026

The Japanese translation of ICRP Publication 147 has been published online by the Nuclear Regulation Authority, Japan.

Dr. Fukunaga served as a member of the Japanese Translation Committee of ICRP Publications.

Click here for the Japanese translation of ICRP Publication 147 (Japanese).

January 30, 2026

Our research paper has been published online in Redox Biology.

Seino R, Fukunaga H. Intergenerational and organ-specific alterations in mitochondrial DNA copy number following preconception irradiation.

Click here for the journal website of our article.

Click here for the press release (Japanese).

January 4, 2026

Our research paper has been published online in MedComm.

Fukunaga H, Seino R, Matsuya Y, Takashima H, Ishikawa M, Onodera Y, Shirato H, Miyata H, Prise KM. Longitudinal Analysis of Male Fertility Using an Acr-Luc Knock-In Mouse Model: A Preclinical Platform for Reproductive Toxicity Testing.

Click here for the journal website of our article.

Click here for the press release.

Click here for the press release (Japanese).